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Les évènements à l'UPMC - L'année internationale de la chimie à l'UPMC


Le mot du doyen de l'UFR de chimie (2011)

L'année 2011 était marquée par deux événements majeurs pour la communauté des chimistes de l'UPMC : la commémoration du centenaire du prix Nobel de Chimie de Marie Curie d'une part et les manifestations réalisées dans le cadre de l'Année Internationale de la Chimie (AIC) d'autre part.

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La chimie à l'UPMC, c'est :

  • 1 Faculté
  • 4 fédérations de recherche
  • 12 laboratoires
  • 5 écoles doctorales
  • 1 licence
  • 4 licences professionnelles
  • 1 master
  • 2300 personnels et étudiants

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Ces activités font partie de  notre programme, déposé en juillet 2010 auprès du comité national AIC2011 et qui a obtenu le label officiel sous le No 117.

Voici le PDF du projet AIC - UPMCNouvelle fenêtre

Using a small molecule to elucidate molecular targets for cardiovascular disease in women

 Dr Tammy Dugas

Louisiana State University, Bâton Rouge, U.S.A.

Amphithéâtre Astier, Bâtiment Esclangon, Campus Jussieu

30 juin 2015, 16 h 45 – 18 h (thé à 16 h 30)


Résumé – Toxicology is an evolving field of study. With its roots in safety assessments for environmental or pharmaceutical exposures, modern toxicology seeks to utilize toxic compounds as tools for the discovery of mechanisms for human disease initiation and progression. Thus, modern toxicology research can facilitate the elucidation of new molecular targets for therapy. A particular case will be presented in which a small organic compound, 4,4’methylenedianiline, was found to promote the initiation of a cardiovascular disease known as pulmonary arterial hypertension (PAH), but only in female animals. These findings are intriguing, in that PAH is a fatal disease that with even the latest therapies, has a poor prognosis, with survival of only ~ 7 years after diagnosis. PAH is  > 3fold more prevalent in women than in men. Thus, the finding of femalespecific disease in the methylenedianiline exposure model may suggest that elucidating the mechanism of action of methylenedianiline could prove useful in revealing targets for future therapies. Research suggesting a potential interaction between methylenedianiline and the estrogen receptor, as well as its ability to alter estrogen metabolism will be discussed, as will the implications of these findings in the context of human disease pathogenesis and pharmacology.

Notes biographiques – Dr. Dugas is a Professor in the Department of Comparative Biomedical Sciences at the Louisiana State University, School of Veterinary Medicine, in Baton Rouge, Louisiana. After receiving her PhD in Chemistry at Louisiana State University, she completed postdoctoral fellowships in Biochemistry, at the Drexel University College of Medicine in Philadelphia, Pennsylvania and in Toxicology, at the University of Texas Medical Branch in Galveston, Texas. Her research emphasis is in discovering the chemical basis of human disease, and in some cases, the utilization of toxic small molecules for the elucidation of novel molecular targets critical to disease pathogenesis. Her research currently focuses on the role of environmental factors in the induction of cardiovascular diseases, particularly those affecting women. Some of Dr. Dugas’ research evolved into two approved patents and the cofounding of a biotech company to develop and commercialize therapies for cardiovascular complications. Outside the laboratory, Dr. Dugas has served on grant review groups for the National Institutes of Health as well as for other groups, both within the US and in other countries. She has also served on several editorial boards, including her role as Associate Editor of Cardiovascular Toxicology and until recently, Reviews Editor for Pharmacological Research.